Medication	Adult dose		Children's dose		Follow-up/comments
Epinephrine*	0.3 to 0.5 mg IM of a 1:1,000 solution of aqueous epinephrine		0.01 mg per kg IM up to a maximal dose of 0.3 to 0.5 mg		About 20 percent of patients will have recurrence within several hours; therefore, a four-hour monitoring period is recommended
Diphenhydramine (Benadryl)	50 mg IM or orally		1 mg per kg IM or orally up to a maximal dose of 50 mg		Dose can be repeated every four to six hours
					12.5 mg per 5 mL liquid preparation available for children
Ranitidine (Zantac)	50 mg IM or IV or 150 mg orally twice daily		2 to 4 mg per kg IV every eight hours up to maximal dose of 50 mg or 2 to 4 mg per kg orally daily (divided into two doses) up to maximal dose of 300 mg per day		Dose can be repeated every 12 hours
Systemic corticosteroids†	Dexamethasone 6 to 10 mg IV, IM, or orally		Methylprednisolone (Solu-Medrol) 1 to 2 mg per kg IV		Usually not repeated