Clinical manifestations of infection	Infection severity
Wound lacking purulence or any manifestations of inflammation (i.e., erythema, pain, tenderness, warmth, or induration)	Not infected
Presence of purulence and/or two or more manifestations of inflammation, but any cellulitis or erythema extends 2 cm or less around the ulcer; infection is limited to the skin or superficial subcutaneous tissues; no other local complications or systemic illness	Mild
Infection (purulence and/or two or more manifestations of inflammation) in a patient who is systemically well and metabolically stable, but who has at least one of the following characteristics: cellulitis extending more than 2 cm around the ulcer; lymphangitic streaking; spread beneath the superficial fascia; deep tissue abscess; gangrene; involvement of muscle, tendon, joint, or bone	Moderate
Infection (purulence and/or two or more manifestations of inflammation) in a patient with systemic toxicity or metabolic instability (e.g., fever, chills, tachycardia, hypotension, confusion, vomiting, leukocytosis, acidosis, severe hyperglycemia, azotemia)	Severe