| Obtain serum ferritin and consider replacing iron in patients with RLS with ferritin level less than 50 ng per mL (50 mcg per L). | C | 9, 14 | Expert panel and nonrandomized trial |
| Consider changing medications that may exacerbate symptoms of RLS. | C | 14 | Expert panel recommendation |
| If antidepressant therapy is used for patients with RLS, consider using bupropion (Wellbutrin). | C | 14, 16 | Expert panel and disease-oriented data showing decreased PLMS with bupropion compared with SSRIs |
| Dopamine agonists are effective treatment for moderate to severe RLS and are the preferred agents for most patients with daily RLS symptoms. | A | 14, 17–24 | Expert advice and RCTs with consistent findings |