Condition	Distinguishing features
Akathisia	An internal desire to move, most commonly associated with the use of neuroleptic medications; desire to move not necessarily associated with discomfort in the legs; symptoms are not worse at night
Nocturnal leg cramps	Sudden involuntary muscle contractions; palpable tightening of the leg muscles
Peripheral neuropathy	Etiologies include trauma, nerve compression, diabetes, nutritional disorders, infections, others; generally causes sensory disturbance; may or may not be more noticeable at night; not typically relieved by activity
Peripheral vascular disease	Primarily a consequence of atherosclerosis; cramping-type pains that are exacerbated by activity and improve with rest; symptoms not worse at night