Intermittent RLS*
Nonpharmacologic therapies
	Administer iron replacement in patients who are iron-deficient
	Consider effect of medications that may enhance RLS
	Recommend mental alerting activities
	Suggest abstinence from caffeine, nicotine, and alcohol
Medications
	Benzodiazepines
	Carbidopa/levodopa (Sinemet)
	Dopamine agonists
	Low-potency opioids
Daily RLS†
Nonpharmacologic therapy
Dopamine agonists (drug of choice in most people with RLS)
Gabapentin (Neurontin); if ineffective as first-line therapy, a dopamine agonist should be considered
Low-potency opioids; if ineffective as first-line therapy, a dopamine agonist should be considered
Refractory RLS‡(Consider referral to subspecialist)
Change to different dopamine agonist
Change to gabapentin
Change to a high-potency opioid or tramadol (Ultram)
Consider adding a second agent, such as gabapentin, a benzodiazepine, or an opioid