Initial phase			Continuation phase			Rating (evidence)
Regimen	Drugs	Interval and doses* (minimal duration)	Regimen	Drugs	Interval and doses*† (minimal duration)	Range of total doses (minimal duration)	HIV−	HIV+
1	Isoniazid Rifampin	Seven days per week for 56 doses (eight weeks) or five days per week for 40 doses (eight weeks)‡	1a	Isoniazid/rifampin	Seven days per week for 126 doses (18 weeks) or five days per week for 90 doses (18 weeks)‡	182 to 130 (26 weeks)	A (I)	A (II)
	Pyrazinamide		1b	Isoniazid/rifampin	Twice weekly for 36 doses (18 weeks)	92 to 76 (26 weeks)	A (I)	A(II)§
	Ethambutol		1c∥	Isoniazid/rifapentine	Once weekly for 18 doses (18 weeks)	74 to 58 (26 weeks)	B (I)	E (I)
2	Isoniazid	Seven days per week for 14 doses (two weeks), then twice weekly for 12 doses (six weeks) or five days per week for 10 doses (two weeks),‡ then twice weekly for12 doses (six weeks)	2a	Isoniazid/rifampin	Twice weekly for 36 doses (18 weeks)	62 to 58 (26 weeks)	A (II)	B (II)§
	Rifampin Pyrazinamide Ethambutol		2b∥	Isoniazid/rifapentine	Once weekly for 18 doses (18 weeks)	44 to 40 (26 weeks)	B (I)	E (I)
3	Isoniazid	Three times weekly for 24 doses (eight weeks)	3a	Isoniazid/rifampin	Three times weekly for 54 doses (18 weeks)	78 (26 weeks)	B (I)	B (II)
	Rifampin
	Pyrazinamide
	Ethambutol
4	Isoniazid Rifampin	Seven days per week for 56 doses (eight weeks) or five days per week for 40 doses (eight weeks)‡	4a	Isoniazid/rifampin	Seven days per week for 217 doses (31 weeks) or five days per week for 155 doses (31 weeks)‡	273 to 195 (39 weeks)	C (I)	C (II)
	Ethambutol		4b	Isoniazid/rifampin	Twice weekly for 62 doses (31 weeks)	118 to 102 (39 weeks)	C (I)	C (II)