| What are the effects of treatments for acute diarrhea in adults living in resource-rich countries? |
| Likely to be beneficial | Antimotility agents |
| Antisecretory agents |
| Trade-off between benefits and harms | Antibiotics (empiric use for mild-to-moderate diarrhea) |
| Unknown effectiveness | Antibiotics plus antimotility agents |
| Restricted diet |
| Oral rehydration solutions |
| What are the effects of treatments for mild-to-moderate traveler's diarrhea in adults from resource-rich countries traveling to resource-poor countries? |
| Likely to be beneficial | Antibiotics (empiric use) |
| Antimotility agents |
| Bismuth subsalicylate (reduced duration of diarrhea compared with placebo, but less effective than loperamide) |
| Trade-off between benefits and harms | Antisecretory agents |
| Unknown effectiveness | Antibiotics plus antimotility agents |
| Restricted diet |
| Oral rehydration solutions |
| What are the effects of treatments for mild-to-moderate diarrhea in adults living in resource-poor countries? |
| Likely to be beneficial | Antimotility agents |
| Antisecretory agents |
| Unknown effectiveness | Antibiotics (empiric use) |
| Antibiotics plus antimotility agents |
| Oral rehydration solutions |
| What are the effects of treatments for severe diarrhea in adults living in resource-poor countries? |
| Beneficial | Amino acid–based oral rehydration solutions |
| Rice-based oral rehydration solution |
| Standard oral rehydration solution* |
| Unknown effectiveness | Antibiotics (empiric use) |
| Antibiotics plus antimotility agents |
| Antimotility agents |
| Antisecretory agents |
| Bicarbonate oral rehydration solution |
| Intravenous rehydration (compared with nasogastric tube rehydration or oral rehydration solution alone) |
| Reduced osmolarity oral rehydration solution |