Classification		% of patients	Characteristics
Classical		92 to 97
	Nodular sclerosis	60 to 80*	Tends to affect adolescents and young adults; usually presents as localized disease; generally good prognosis
	Mixed cellularity	15 to 30*	More prevalent in children and older adults; often diagnosed at a more advanced stage (therefore, has a somewhat poorer prognosis); associated with HIV infection
	Lymphocyte rich	2 to 7*	Reed-Sternberg cells have a more classical immunophenotype; tends to present at an early stage; good prognosis
	Lymphocyte depleted	1 to 6*	Mainly in older adults; often diagnosed at advanced stage; poor prognosis
Nodular lymphocyte–Predominant		3 to 8	Lacks typical Reed-Sternberg cells; shows atypical lymphocytic and histiocytic cells; usually localized disease with indolent course; good prognosis