| Analgesics | |
| Acetaminophen, aspirin | Chronic interstitial nephritis |
| Nonsteroidal anti-inflammatory drugs | Acute interstitial nephritis, altered intraglomerular hemodynamics, chronic interstitial nephritis, glomerulonephritis |
| Antidepressants/mood stabilizers | |
| Amitriptyline (Elavil*), doxepin (Zonalon), fluoxetine (Prozac) | Rhabdomyolysis |
| Lithium | Chronic interstitial nephritis, glomerulonephritis, rhabdomyolysis |
| Antihistamines | |
| Diphenhydramine (Benadryl), doxylamine (Unisom) | Rhabdomyolysis |
| Antimicrobials | |
| Acyclovir (Zovirax) | Acute interstitial nephritis, crystal nephropathy |
| Aminoglycosides | Tubular cell toxicity |
| Amphotericin B (Fungizone*; deoxycholic acid formulation more so than the lipid formulation) | Tubular cell toxicity |
| Beta lactams (penicillins, cephalosporins) | Acute interstitial nephritis, glomerulonephritis (ampicillin, penicillin) |
| Foscarnet (Foscavir) | Crystal nephropathy, tubular cell toxicity |
| Ganciclovir (Cytovene) | Crystal nephropathy |
| Pentamidine (Pentam) | Tubular cell toxicity |
| Quinolones | Acute interstitial nephritis, crystal nephropathy (ciprofloxacin [Cipro]) |
| Rifampin (Rifadin) | Acute interstitial nephritis |
| Sulfonamides | Acute interstitial nephritis, crystal nephropathy |
| Vancomycin (Vancocin) | Acute interstitial nephritis |
| Antiretrovirals | |
| Adefovir (Hepsera), cidofovir (Vistide), tenofovir (Viread) | Tubular cell toxicity |
| Indinavir (Crixivan) | Acute interstitial nephritis, crystal nephropathy |
| Benzodiazepines | Rhabdomyolysis |
| Calcineurin inhibitors | |
| Cyclosporine (Neoral) | Altered intraglomerular hemodynamics, chronic interstitial nephritis, thrombotic microangiopathy |
| Tacrolimus (Prograf) | Altered intraglomerular hemodynamics |
| Cardiovascular agents | |
| Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers | Altered intraglomerular hemodynamics |
| Clopidogrel (Plavix), ticlopidine (Ticlid) | Thrombotic microangiopathy |
| Statins | Rhabdomyolysis |
| Chemotherapeutics | |
| Carmustine (Gliadel), semustine (investigational) | Chronic interstitial nephritis |
| Cisplatin (Platinol) | Chronic interstitial nephritis, tubular cell toxicity |
| Interferon-alfa (Intron A) | Glomerulonephritis |
| Methotrexate | Crystal nephropathy |
| Mitomycin-C (Mutamycin) | Thrombotic microangiopathy |
| Contrast dye | Tubular cell toxicity |
| Diuretics | |
| Loops, thiazides | Acute interstitial nephritis |
| Triamterene (Dyrenium) | Crystal nephropathy |
| Drugs of abuse | |
| Cocaine, heroin, ketamine (Ketalar), methadone, methamphetamine | Rhabdomyolysis |
| Herbals | |
| Chinese herbals with aristocholic acid | Chronic interstitial nephritis |
| Proton pump inhibitors | |
| Lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix) | Acute interstitial nephritis |
| Others | |
| Allopurinol (Zyloprim) | Acute interstitial nephritis |
| Gold therapy | Glomerulonephritis |
| Haloperidol (Haldol) | Rhabdomyolysis |
| Pamidronate (Aredia) | Glomerulonephritis |
| Phenytoin (Dilantin) | Acute interstitial nephritis |
| Quinine (Qualaquin) | Thrombotic microangiopathy |
| Ranitidine (Zantac) | Acute interstitial nephritis |
| Zoledronate (Zometa) | Tubular cell toxicity |