Complication	Treatment
Raynaud phenomenon	α-Adrenergic blockers
	Angiotensin-II receptor blockers
	Long-acting calcium channel blockers (dihydropyridines)
	Pentoxifylline (Trental)
	Stellate ganglionic blockades, digital sympathectomy
Skin fibrosis	Immunomodulatory drugs (d-penicillamine [Cuprimine], mycophenolate mofetil [Cellcept], cyclophosphamide [Cytoxan])
Gastroesophageal reflux disease	Antacids
	Histamine H2 Blockers
	Proton pump inhibitors
Intestinal dysmotility or bacterial overgrowth	Antibiotics
	Correction of nutritional deficiencies
	Promotility agents
Pulmonary fibrosis or alveolitis	Immunomodulatory drugs
	Initial therapy with oral or intravenous cyclophosphamide
	Maintenance therapy with azathioprine (Imuran)
Pulmonary arterial hypertension	Diuretics
	Endothelin-1 receptor inhibitors (bosentan [Tracleer])
	Oxygen
	Phosphodiesterase-5 inhibitors (sildenafil [Revatio])
	Prostacyclin analogues (epoprostenol [Flolan], treprostinil [Remodulin], iloprost [Ventavis])
	Warfarin (Coumadin) is sometimes used in patients with recurrent pulmonary thromboembolic disease secondary to pulmonary arterial hypertension
Scleroderma renal crisis	Dialysis
	Short-acting angiotensin-converting enzyme inhibitors