Factor	LAIV	TIV
Route of administration	Intranasal spray	Intramuscular injection
Number of included virus strains	3 (2 influenza A, 1 influenza B)	3 (2 influenza A, 1 influenza B)
Frequency of updates to vaccine virus strains	Annually	Annually
Frequency of administration	Annually*	Annually*
Approved ages	2 to 49 years †	6 months and older
Interval between doses for children 6 months to 8 years of age who are receiving vaccine for the first time	4 weeks	4 weeks
Can be administered to persons at risk of influenza-related complications†	No	Yes
Can be administered to children with asthma or children 2 to 4 years of age with a history of wheezing during the preceding year‡	No	Yes
Can be administered to close contacts of immunosuppressed persons who do not require a protective environment	Yes	Yes
Can be administered to close contacts of immunosuppressed persons who require a protective environment (e.g., hematopoietic stem cell transplant recipients)	No	Yes
Can be administered to close contacts of persons at high risk, but who are not severely immunosuppressed	Yes	Yes
Can be simultaneously administered with other vaccines	Yes§	Yes‖
If not simultaneously administered, can be administered within 4 weeks of another live vaccine	Prudent to space 4 weeks apart	Yes
If not simultaneously administered, can be administered within 4 weeks of an inactivated vaccine	Yes	Yes