Clinical recommendationEvidence ratingReferences
The target blood pressure in patients with diabetes is less than 130/80 mm Hg.A3, 59
ACE inhibitors and ARBs are preferred agents in the management of patients with hypertension and diabetes.A2, 8, 9, 12, 13
If target blood pressure is not achieved with an ACE inhibitor or ARB, addition of a thiazide diuretic is the preferred second-line therapy for most patients with diabetes.B79, 1820
Beta blockers should be used as part of the initial antihypertensive regimen in patients with diabetes and a history of myocardial infarction, heart failure, coronary artery disease, or stable angina.A79, 11, 23
Dihydropyridine calcium channel blockers should be reserved for patients with diabetes who cannot tolerate preferred antihypertensive agents or those who need additional agents to achieve target blood pressure.A2, 9, 19, 27, 28
Most patients with diabetes require therapy with a combination of antihypertensive agents to achieve target blood pressure.C2, 79