Clinical recommendations	Evidence rating	References
Patients with impaired glucose tolerance should be provided with counseling and instruction for weight loss and physical activity.	A	6, 8
Metformin (Glucophage) is the only medication proven to reduce mortality rates in patients with type 2 diabetes.	A	5
Acarbose (Precose) seems to reduce the risk of cardiovascular disease events.	B	13, 1719–21
When adding insulin to a regimen of oral medication, oral agents should be continued initially. Long-acting insulin should be used initially, typically at a dosage of 10 units per day or 0.17 to 0.5 units per kg per day, and titrated in increments of two units approximately every three days.	C	14, 24