Drug	Class of antimicrobial	Route of administration	Dosage			Duration of therapy	Cost*
Primary treatment (recommended by current guidelines)
Penicillin V (Veetids; brand no longer available in the United States)	Penicillin	Oral	Children: 250 mg two to three times per day			10 days	$4
			Adolescents and adults: 250 mg three to four times per day
			or
			500 mg two times per day
Amoxicillin	Penicillin (broad spectrum)	Oral	Children (mild to moderate GABHS pharyngitis):			10 days	$4
			12.25 mg per kg two times per day
			or
			10 mg per kg three times per day
			Children (severe GABHS pharyngitis): 22.5 mg per kg two times per day
			or
			13.3 mg per kg three times per day
			or
			750 mg (not FDA approved) once per day†
			Adults (mild to moderate GABHS pharyngitis):
			250 mg three times per day
			or
			500 mg two times per day
			Adults (severe GABHS pharyngitis): 875 mg two times per day
Penicillin G benzathine (Bicillin L-A)	Penicillin	Intramuscular	Children: < 60 lb (27 kg): 6.0 × 105 units			One dose	Varies
			Adults: 1.2 × 106 units
Treatment for patients with penicillin allergy (recommended by current guidelines)
Erythromycin ethylsuccinate	Macrolide	Oral	Children: 30 to 50 mg per kg per day in two to four divided doses			10 days	$4
			Adults: 400 mg four times per day or 800 mg two times per day
Erythromycin estolate	Macrolide	Oral	Children: 20 to 40 mg per kg per day in two to four divided doses			10 days	$4
			Adults: not recommended‡
Cefadroxil (Duricef; brand no longer available in the United States)	Cephalosporin (first generation)	Oral	Children: 30 mg per kg per day in two divided doses			10 days	$45
			Adults: 1 g one to two times per day
Cephalexin (Keflex)	Cephalosporin (first generation)	Oral	Children: 25 to 50 mg per kg per day in two to four divided doses			10 days	$4
			Adults: 500 mg two times per day