| Acetaminophen | Acetaminophen | Abdominal pain, nausea/vomiting, elevated aspartate transaminase level (greater than 1,000 IU per L after 24 hours), jaundice, confusion, somnolence, coma, disorientation | N-acetylcysteine (Acetadote) |
| Anticholinergic | Antihistamines, atropine (Atreza), belladonna alkaloids, toxic mushrooms, psychoactive drugs | Tachycardia, hyperthermia, mydriasis, warm and dry skin, urinary retention, ileus, delirium | — |
| Anticoagulant | Warfarin (Coumadin), rodenticides | Ecchymoses, bleeding, prolonged prothrombin and bleeding times | Vitamin K |
| Cardiac medication | Calcium channel blockers, beta blockers, digoxin | Bradycardia, arrhythmias, hypotension, dizziness, heart block, nausea, vomiting | Calcium chloride, glucagons (Glucagen), digoxin immune fab (Digibind) |
| Cholinergic, muscarinic | Carbamates, some mushrooms, organophosphates, physostigmine, pilocarpine (Isopto Carpine), pyridostigmine | Salivation, lacrimation, urination, diarrhea, bronchorrea, wheezing, bradycardia, vomiting | Atropine/pralidoxime (not available in the United States) |
| Cholinergic, nicotinic | Black widow spider bites, carbamates, insecticides, nicotine | Tachycardia, hypertension, fasciculations, gastrointestinal cramps, emesis, miosis | Atropine/pralidoxime (not available in the United States) |
| Cyanide | Cyanide | Syncope, cyanosis, hypotension, psychosis | Sodium nitrite 3%, sodium thiosulfate 25% |
| Ethylene glycol, methanol | Antifreeze, rubbing alcohol | Central nervous system depression, respiratory depression, seizures, hypotension, hypoglycemia | Ethanol 10% or fomepizole (Antizol) |
| Iron | Iron-containing products | Dyspepsia, nausea, vomiting, diarrhea, dark stools | Deferoxamine (Desferal) |
| Opioid | Opioids (e.g., morphine, hydrocodone [Hycodan], methadone) | Hypoventilation, hypotension, miosis, sedation, hypothermia, ileus | Short-acting naloxone (Narcan; brand no longer available in the United States), monitor closely for withdrawal symptoms and relapsing sedation |
| Salicylate | Aspirin products | Tinnitus, nausea, vomiting, fever, disorientation, lethargy, tachypnea | — |
| Sulfonylurea | Sulfonylurea | Hypoglycemia, tachycardia, diaphoresis, clammy skin, mental status changes, coma | Octreotide (Sandostatin) |
| Sympathomimetic | Amphetamines, caffeine, cocaine, ephedrine, 3,4-methylenedioxymethamphetamine (also called Ecstasy), phenylpropanolamine (no longer available in the United States), theophylline, diphenoxylate/atropine (Lomotil) | Tachycardia, hypertension, mydriasis, agitation, seizures, diaphoresis, psychosis, hyperthermia | — |