| Clinical recommendation | Evidence rating | References |
|---|---|---|
| The muscarinic agonists pilocarpine (Salagen) and cevimeline (Evoxac) can be used to relieve xerophthalmia in patients with Sjögren syndrome. | B | 21, 22 |
| Muscarinic agonists improve subjective and objective signs and symptoms of xerostomia in patients with Sjögren syndrome. | B | 25, 26 |
| Interferon alfa improves subjective oral and ocular dryness and increases nonstimulated saliva flow in patients with Sjögren syndrome. | B | 7 |