Therapy*	Dosage	Adverse effects	Cost of generic (brand)†	In retail discount programs‡
Doxycycline	40 (subantimicrobial dose therapy) to 100 mg once or twice per day for six to 12 weeks	GI upset, allergic reactions, photosensitivity	40 mg: NA ($236) 100 mg: $20 ($70)	✓
		Drug interactions: antacids, anticoagulants
		Contraindicated in pregnant and lactating women
Tetracycline	250 to 500 mg twice per day for six to 12 weeks; intermittent, low-dose therapy when indicated	GI upset, candida, photosensitivity	$15 (NA)	✓
		Drug interactions: antacids, anticoagulants
		Contraindicated in pregnant and lactating women
Minocycline (Minocin)	50 to 100 mg twice per day or sustained-action formula once per day for six to 12 weeks	GI upset, allergic reactions, vertigo, photosensitivity	$32 ($273)
		Drug interactions: antacids, anticoagulants
		Contraindicated in pregnant and lactating women
Metronidazole (Flagyl)	250 mg once per day for four to six weeks	Disulfiram-like reaction possible, headache	$34 ($189)	✓
		Rare neuropathy, seizures
		Drug interactions: lithium, anticoagulants, phenytoin (Dilantin)
Azithromycin	500 mg on day 1, followed by 250 mg daily for four days	GI upset, candida, cholestasis	$99 ($312)
		Drug interactions: erythromycin
Isotretinoin (Accutane)	0.5 to 1 mg per kg, divided, twice per day for 10 to 60 days (only for severely recalcitrant nodular rosacea)	Teratogenicity, hypercholesterolemia, hypertriglyceridemia, musculoskeletal changes, hepatotoxicity, decreased night vision, mood changes (e.g., depression)	NA ($350)
		Drug interactions: vitamin A supplements