Condition	Characteristics
Neurofibromatosis 1	Café au lait spots or other light-colored to brown macules; associated with multiple neural tumors; macules usually increase in size and number with age
Peutz-Jeghers syndrome	Melanotic macules, usually on the lips and mucous membranes, with gastrointestinal polyposis; macules may develop on the hands, feet, nose, and around the eyes and umbilicus; macules are up to 2 cm in size
Urticaria pigmentosa	Macular, nodular, or popular lesions ranging in color from dark yellow to brown; often symmetrically distributed; erythema and whealing (Darier sign); dermographism of normal skin is often present
Xeroderma pigmentosum	Affects sun-exposed skin, such as on the face, arms, and legs; reddening of the skin with scaling; freckling; irregular dark spots, which may be premalignant