brand logo

Am Fam Physician. 2009;80(11):1223

I was recently diagnosed with common variable immunodeficiency (CVID). When I got the diagnosis, I was happy: “Finally, redemption—I'm not a hypochondriac, my B cells are lazy!” My complaints were always generalized and centered on fatigue. Like so many others in this situation, I was referred to a psychiatrist and prescribed antidepressants. I didn't really understand the full scope of things. I wish the doctors had spent more time explaining that Prozac wasn't a magic pill and that I needed to make some lifestyle changes. I also wish the doctors had followed up to make sure it wasn't anything physiological.

The psychiatric medication never worked. I took everything out there, and all of it made me horribly sick. That period was awful. It hurt my relationships. I quit my master's degree program. I was betting it all on a magic pill, and I started ignoring basic things like getting a job I could manage, going for walks, and even eating properly. My worldview changed.

Up until two years ago, no doctor had ever asked me what I thought was wrong. I'll never forget the day when my new doctor asked me, “What do you think is going on?” She didn't flinch when I used some of the medical terminology I'd learned on the Internet. Like so many chronically ill patients, I didn't go to medical school, but I've spent a long time reading up on different conditions. She also took what I said seriously.

Neither of us gave up. She eventually ordered a celiac disease test, which caught the low immunoglobulin A level that led to the diagnosis of CVID.

Now I have this diagnosis, and it's tough because it's another “mystery disease.” When will I get better and how much better will I get? Nobody knows. I just keep telling myself, three months. When three months pass, I just give it three more months. I scrutinize everything, every little detail of my disease. But for some reason, the three-month rule is something that has worked for me.—g.e.


This patient had a number of vague symptoms, making it plausible that an underlying psychiatric diagnosis was the culprit. However, there were a few symptoms, such as persistent diarrhea and intolerance to certain foods, that made me pursue the diagnosis of celiac disease, ultimately uncovering the CVID. Although this diagnosis does not fully explain all of his symptoms, the idea of a disease that can explain at least some of his symptoms is a relief in itself.

Continue Reading

More in AFP

More in PubMed

Copyright © 2009 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.