Clinical recommendation	Evidence rating	References
Switching to low-protein, powder-free latex gloves or to latex-free gloves provides a primary prevention of latex allergy.	C	10, 13–15, 28
Serum IgE measurement is considered the most useful test for confirming suspected severe latex allergy and carries no risk of anaphylaxis. Glove provocation testing is useful when the patient's clinical history is incongruent with IgE results, although it is not considered first-line testing. Skin patch testing is sensitive for diagnosing type IV delayed allergy symptoms.	C	2, 3, 12
Children with spina bifida or urogenital anomalies, or those who may have multiple surgical procedures, should avoid latex exposure from birth to prevent the development of latex allergy.	C	7, 8, 26, 27
Sublingual immunotherapy with latex may be effective in patients with severe latex allergy, especially in patients who cannot avoid all exposure to latex.	B	30–32