Clinical recommendationEvidence ratingReferences
Men younger than 40 years with limited episodes of hematospermia and no risk factors or associated symptoms can be evaluated for common genitourinary diseases, treated if indicated, and reassured.C1
Men with hematospermia who are 40 years and older, have associated symptoms, or have persistent hematospermia need more extensive evaluation, including assessment for underlying prostate cancer.C4
Low-volume hematospermia associated with iatrogenic etiologies is often self-limiting; therefore, observation is the most appropriate management strategy.C4