Drug class	Examples	Risks
Aminoglycosides, injectable	Tobramycin, gentamicin	Ototoxicity, nephrotoxicity
Angiotensin-converting enzyme inhibitors	Enalapril (Vasotec), lisinopril (Zestril)	Injury or death to developing fetus
Angiotensin receptor blockers	Irbesartan (Avapro), valsartan (Diovan)	Injury or death to developing fetus
Beta blockers	Metoprolol, atenolol (Tenormin)	Exacerbation of angina and risk of MI with abrupt discontinuation
Calcineurin inhibitors, topical	Pimecrolimus cream (Elidel), tacrolimus ointment (Protopic)	Malignancy (causation not proven); avoid continuous long-term use; not indicated for use in patients younger than two years
Diuretics, loop	Furosemide (Lasix), bumetanide	Volume and electrolyte depletion
Estrogen	Estradiol in various preparations	MI, stroke, deep venous thrombosis, pulmonary embolism, and breast cancer in postmenopausal women
Iron supplements, oral	Ferrous sulfate, many vitamin supplements	Overdose may be fatal in children
Nonsteroidal anti-inflammatory drugs	Naproxen (Naprosyn), ibuprofen	Cardiovascular events, ulcers, and gastrointestinal bleeding
Oral contraceptives, combined	Various estrogens and progesterones	Increased cardiovascular risk in smokers, especially in those older than 35 years
Salicylates	Aspirin	Reye syndrome in children; potential for serious allergic reaction
Selective serotonin reuptake inhibitors	Fluoxetine (Prozac), duloxetine (Cymbalta)	Increased suicidality in children and adolescents