RegimenMedication
Recommended prophylaxisPenicillin G: initial dose of 5 million units IV, then 2.5 million units IV every four hours until delivery
Alternative prophylaxisAmpicillin: initial dose of 2 g IV, then 1 g IV every four hours until delivery
For patients who are allergic to penicillin
Not at high risk of anaphylaxisCefazolin: initial dose of 2 g IV, then 1 g IV every eight hours until delivery
At high risk of anaphylaxis and GBS susceptible to clindamycin (Cleocin) and erythromycinClindamycin: 900 mg IV every eight hours until delivery
or
Erythromycin: 500 mg IV every six hours until delivery
At high risk of anaphylaxis and GBS resistant to clindamycin or erythromycin, or GBS susceptibility unknownVancomycin: 1 g every 12 hours until delivery