| Adverse effect | Low-potency FGAs† | High-potency FGAs‡ | SGAs | |||||
|---|---|---|---|---|---|---|---|---|
| Aripiprazole (Abilify) | Clozapine (Clozaril) | Olanzapine (Zyprexa) | Quetiapine (Seroquel) | Risperidone (Risperdal) | Ziprasidone (Geodon) | |||
| Anticholinergic effects | +++ | + | 0 | +++ | + | + | 0 | 0 |
| Dyslipidemia | ++ | + | 0 | +++ | +++ | ++ | + | 0 |
| Extrapyramidal symptoms | + | +++ | + | 0 | + | 0 | ++ | + |
| Hyperprolactinemia | ++ | +++ | 0 | 0 | + | 0 | +++ | + |
| Neuroleptic malignant syndrome | + | ++ | + | + | + | + | + | + |
| Postural hypotension | +++ | + | + | +++ | + | ++ | ++ | + |
| Prolonged QT interval | ++§ | + | + | + | + | + | + | ++ |
| Sedation | +++ | + | + | +++ | ++ | ++ | + | + |
| Seizures | + | + | + | +++ | + | + | + | + |
| Sexual dysfunction | +++ | ++ | + | + | + | + | ++ | + |
| Type 2 diabetes mellitus | + | + | + | ++ | ++ | + | + | + |
| Weight gain | ++ | + | 0 | +++ | +++ | ++ | ++ | 0 |