| Initial evaluation of a patient with peripheral neuropathy should include a complete blood count, comprehensive metabolic profile, and measurement of erythrocyte sedimentation rate and fasting blood glucose, vitamin B12, and thyroid-stimulating hormone levels. | C | 5 |
| Electrodiagnostic studies are recommended if symptoms persist and if the diagnosis remains unclear after initial diagnostic testing and a careful history and physical examination. | C | 4, 5 |
| Options for symptomatic treatment of peripheral neuropathy include antiseizure medications, tricyclic antidepressants, and topical medications. | B | 13–18 |