Clinical conditionHistoryVital signsClinical features
Anticholinergic syndromeUse of tricyclic antidepressants or other anticholinergic drugsTachycardia, tachypnea, hyperthermia (usually 102.2°F [39°C] or below)Dry mouth, blurred vision, mydriasis, flushed skin, agitation/delirium, decreased bowel sounds
Malignant hyperthermiaAdministration of halogenated inhalational anesthetics or depolarizing muscle relaxantsHypertension, tachycardia, tachypnea, hyperthermia (up to 114.8°F [46°C])Diaphoresis, mottled skin, agitation, decreased bowel sounds, muscular rigidity, hyporeflexia
Neuroleptic malignant syndromeIngestion of antipsychotic medicationsHypertension, tachycardia, tachypnea, hyperthermia (above 105.8°F [41°C])Sialorrhea, diaphoresis, pallor, stupor, mutism, coma, normal or decreased bowel sounds, lead-pipe rigidity, bradyreflexia