| Selective serotonin reuptake inhibitors improve depression in patients receiving chemotherapy. | B | 6, 7 | RCTs of paroxetine (Paxil) |
| Patients with cancer should be assessed for fatigue at regular intervals. | C | 51 | Recommendation from consensus guideline |
| 5-hydroxytryptamine3 receptor antagonists (such as ondansetron [Zofran]) are recommended first-line therapy for radiation-induced emesis. | B | 33 | Recommendation from evidence-based practice guideline |
| Adding dexamethasone (4 mg daily for five days) to ondansetron therapy provides additional prophylaxis against radiation-induced emesis. | B | 33, 34 | Consistent findings from small RCT34 and recommendation from evidence-based practice guideline33 |
| Phosphodiesterase type 5 inhibitors, such as sildenafil (Viagra) and tadalafil (Cialis), are effective for erectile dysfunction associated with radiation therapy. | A | 42–44 | Consistent findings from RCTs of sildenafil and tadalafil |
