Disease	Population usually affected	Appearance of lesions	Pain	Drainage	Histology	Associations
Condylomata acuminata	Sexually active	Gray-tan, cauliflower-like, turns white with application of dilute acetic acid	Present	Present	Koilocytosis	Genital lesions, pruritus, sex partner with similar lesions
Condylomata lata	Sexually active	Soft, flat, pink	Absent	Copious	Corkscrew Treponema pallidum	Maculopapular rash, positive results on rapid plasma reagin and Venereal Disease Research Laboratories testing
External hemorrhoids	Older than 50 years, pregnant, chronically constipated	Red-purple, tense on palpation	Present	Bloody	Smooth muscle, connective tissue, vascular tissue	Improvement with treatment
Hidradenitis suppurativa	Between puberty and 40 years of age	Nodular, sinus tracts	Present	Malodorous	Inflamed apocrine tissue	Hyperhydrosis, oily skin, lesions in groin/axilla, family history
Perianal Crohn's disease	15 to 35 and 55 to 75 years of age	Large, edematous, “elephant ear,” bluish or skin- colored tags	Absent (accompnying fissures may be painful)	Absent	Granulomatous inflammation	Systemic symptoms of Crohn's disease, nonhealing, fissures