Maternal HBsAg status	Newborn care
Negative	Give hepatitis B vaccine before discharge, preferably within 12 hours of birth
	If birth weight is less than 4 lb, 6 oz (2,000 g): postpone first dose of vaccine until one month of age
Positive	Give hepatitis B immune globulin and hepatitis B within 12 hours of birth
	Complete vaccine series by six months of age
	Obtain follow-up serology (HBsAg and hepatitis B surface antibody) between nine and 18 months of age
	If birth weight is less than 4 lb, 6 oz: give birth dose, but do not count as part of the three-dose series, and give next dose at one month of age (will receive four total doses)
Unknown (maternal HBsAg result not available within 12 hours of birth)	Give hepatitis B vaccine within 12 hours of birth
	Obtain maternal HBsAg immediately; if mother is HBsAg positive, give hepatitis B immune globulin immediately and within seven days of birth, then proceed with above recommendations for positive HBsAg maternal status
	If birth weight is less than 4 lb, 6 oz, and maternal HBsAg status returns as positive or remains unknown within 12 hours of birth, then proceed with above recommendations for positive HBsAg maternal status