ConditionCharacteristics
Adrenocortical carcinomaGenerally functional (hormone-producing); virilization common in girls; diagnosed with computed tomography of adrenal glands
Nonclassic congenital adrenal hyperplasiaNo signs or symptoms at birth, unlike classic form; hyperandrogenemia leads to symptoms in childhood or early adulthood; elevated basal 17-OHP levels are diagnostic, but corticotropin stimulation test warranted if 17-OHP levels are normal
Premature adrenarchePrecocious activation of zona reticularis for unknown reasons; pubic hair before eight years of age without other signs of puberty; normal androgen levels
Sex cord-stromal tumorsArise from gonadal nongerminative component; often functional; may produce androgens leading to clinical manifestations of hyperandrogenism; ovarian imaging findings abnormal