| First-line therapy |
| Amoxicillin (regular dose) | 83 to 88 | 500 mg every eight hours for 10 days | 500-mg tablets: $29 |
| or | 500-mg capsules: $15† |
| 875 mg every 12 hours for 10 days | 875-mg tablets: $27 |
| For coverage of beta-lactamase–producing Moraxella catarrhalis and Haemophilus influenzae |
| Amoxicillin/clavulanate (Augmentin; regular dose) | 90 to 92 | 500 mg/125 mg every eight hours for 10 days | 500-mg/125-mg tablets: $69 ($167) |
| or | |
| 875 mg/125 mg every 12 hours for 10 days | 875-mg/125-mg tablets: $48 ($219) |
| Alternatives to amoxicillin/clavulanate |
| Cefdinir (Omnicef) | 83 to 88 | 300 mg twice per day for 10 days | 300-mg capsules: $40 ($114) |
| or |
| 600 mg per day for 10 days |
| Cefpodoxime | 83 to 88 | 200 mg twice per day for 10 days | 200-mg tablets: $114 |
| Cefuroxime (Ceftin) | 83 to 88 | 250 mg twice per day for 10 days | 250-mg tablets: $71 ($214) |
| Alternatives to penicillin |
| Trimethoprim/sulfamethoxazole (Bactrim, Septra) | 83 to 88 | 800 mg/160 mg twice per day for 10 days | 800-mg/160-mg tablets: $17† ($49) |
| Azithromycin (Zithromax) | 77 to 81 | 500 mg per day for three days | 500-mg tablets: $44 ($74) |
| Clarithromycin (Biaxin), regular or XR | 77 to 81 | 500 mg twice per day for 14 days | 500-mg tablets: $103 ($181) |
| or | |
| 1,000 mg XR every day for 14 days | 500-mg XR tablets: $135 ($189) |
| For possibleStreptococcus pneumoniaeresistance (e.g., child in household who attends day care) |
| Amoxicillin (high dose) | 83 to 88 | 1 g every eight hours for 10 days | 500-mg tablets: $31 |
| or | 500-mg capsules: $19† |
| 1 g four times per day for 10 days | 500-mg tablets: $42 |
| 500-mg capsules: $25 |
| For moderate disease, recent antibiotic use, or treatment failure |
| Amoxicillin/clavulanate, XR (Augmentin XR) | 90 to 92 | 2,000 mg/125 mg twice per day for 10 days | 1,000-mg/62.5-mg tablets: NA ($167) |
| Levofloxacin (Levaquin) | 90 to 92 | 500 mg per day for 10 to 14 days | 500-mg tablets: NA ($186) |
| or | |
| 750 mg every day for five days | 750-mg tablets: NA ($159) |
| Moxifloxacin (Avelox) | 90 to 92 | 400 mg per day for 10 days | 400-mg tablets: NA ($653) |
