| Anticonvulsants | Gabapentin (Neurontin) | 1,800 to 3,600 mg per day | $93 to $186 ($365 to $729) | 2.8–5.3 | Somnolence, dizziness, edema, dry mouth |
| Pregabalin (Lyrica) | 150 to 600 mg per day | NA ($95 to $190) | 4.9 |
| Opioids | Controlled-release oxycodone (Oxycontin) | Variable | NA ($209, 15-mg 12-hour tablets) | 2.7 | Constipation, nausea, vomiting, sedation, dizziness, dependence |
| Long-acting morphine | Variable | $64 ($84), 15-mg 12-hour tablets | 2.7 |
| Tramadol (Ultram) | 100 to 400 mg per day | $34 ($140), 100 mg per day | 4.8 | Dependence |
| Topical agents | Capsaicin 0.075% cream (Zostrix) | Applied three or four times per day | NA ($19 to $25, 2 oz) | 3.3 | Burning skin |
| Lidocaine 5% patch (Lidoderm) | Maximum three patches per day | NA ($217, 30 patches) | 2.0 | Mild skin reaction |
| Tricyclic antidepressants | Amitriptyline† | Up to 150 mg per day | $17 (NA) | 2.6 | Sedation, dry mouth, blurred vision, constipation, urinary retention |
| Desipramine (Norpramin) | Up to 150 mg per day | $140 ($180) |
| Nortriptyline (Pamelor) | Up to 150 mg per day | $19 ($1,082) |
