Class	Medication	Dosage	Cost of generic (brand)*	NNT	Adverse effects
Anticonvulsants	Gabapentin (Neurontin)	1,800 to 3,600 mg per day	$93 to $186 ($365 to $729)	2.8–5.3	Somnolence, dizziness, edema, dry mouth
	Pregabalin (Lyrica)	150 to 600 mg per day	NA ($95 to $190)	4.9
Opioids	Controlled-release oxycodone (Oxycontin)	Variable	NA ($209, 15-mg 12-hour tablets)	2.7	Constipation, nausea, vomiting, sedation, dizziness, dependence
	Long-acting morphine	Variable	$64 ($84), 15-mg 12-hour tablets	2.7
	Tramadol (Ultram)	100 to 400 mg per day	$34 ($140), 100 mg per day	4.8	Dependence
Topical agents	Capsaicin 0.075% cream (Zostrix)	Applied three or four times per day	NA ($19 to $25, 2 oz)	3.3	Burning skin
	Lidocaine 5% patch (Lidoderm)	Maximum three patches per day	NA ($217, 30 patches)	2.0	Mild skin reaction
Tricyclic antidepressants	Amitriptyline†	Up to 150 mg per day	$17 (NA)	2.6	Sedation, dry mouth, blurred vision, constipation, urinary retention
	Desipramine (Norpramin)	Up to 150 mg per day	$140 ($180)
	Nortriptyline (Pamelor)	Up to 150 mg per day	$19 ($1,082)