Drug*	Food restrictions	Renal or hepatic modification	Adverse effects
Efavirenz (Sustiva)	Take on empty stomach at bedtime	Renal	Dizziness, insomnia, headache, inability to concentrate, abnormal dreams, lipoatrophy when used with stavudine (Zerit) or zidovudine (Retrovir), potential teratogenicity, false-positive cannabinoid and benzodiazepine screening assays
Etravirine (Intelence)	Take with food	None	Nausea, peripheral neuropathy, hypertension, hypersensitivity reaction; increased liver function, increased cholesterol and triglyceride levels
Nevirapine (Viramune)	None	Hepatic	Severe hepatotoxicity, liver failure, and death; women with baseline CD4 cell count > 250 per mm3 (0.25 × 109 per L) and men with baseline CD4 > 400 per mm3 (0.40 × 109 per L) are at highest risk