Drug	Food restrictions	Renal or hepatic modification*	Adverse effects
Atazanavir (Reyataz)	Take with food	Hepatic	Asymptomatic indirect hyperbilirubinemia, rash (20% of patients; does not require discontinuation), PR prolongation, kidney stones
			Use with caution in patients with underlying cardiac conduction abnormalities; requires acid in stomach for absorption; see prescribing information for dosing with antacids, histamine H2 blockers, and proton pump inhibitors
Darunavir (Prezista)	Take with food	None	Rash (10% of patients; may be severe and require discontinuation)
			Use with caution in patients with sulfonamide allergy
Fosamprenavir (Lexiva)	None	Hepatic	Perioral paresthesia, rash (19% of patients; may be severe) Use with caution in patients with sulfonamide allergy
Indinavir (Crixivan)	Take 1 hour before or 2 hours after meal; drink 50 oz (1.5 L) of water per day	Hepatic	Indirect hyperbilirubinemia, kidney stones, renal insufficiency, alopecia, dry skin and mucous membranes, paronychia, ingrown toenails, gallstones
Lopinavir/ritonavir (Kaletra)	None (may be better tolerated with food)	None	Potentially fatal pancreatitis, increased risk of myocardial infarction with long-term use, PR and QT prolongation
Nelfinavir (Viracept)	Take with food	None	Diarrhea
Ritonavir (Norvir)	Take with food	Hepatic	Altered taste, circumoral and peripheral paresthesia
Saquinavir (Invirase)	Take within 2 hours of a meal	Hepatic	Rash, prolonged QT interval, hyperprolactinemia (rare)
Tipranavir (Aptivus)	None	Hepatic	Severe hepatitis; intracranial hemorrhage Use with caution in patients with sulfonamide allergy