DrugFood restrictionsRenal or hepatic modification*Adverse effects
Entry inhibitor: maraviroc (Selzentry)NoneNoneCough, fever, upper respiratory symptoms, rash, abdominal pain, orthostatic hypotension, musculoskeletal symptoms; hepatotoxicity may be associated with rash and eosinophilia; increased risk of myocardial infarction (1.3%) compared with placebo in 24-week study17
Fusion inhibitor: enfuvirtide (Fuzeon)NoneNoneInjection site reactions, eosinophilic hypersensitivity reactions (less than 1%) and neutropenia; may increase risk of bacterial pneumonia
Integrase strand transfer inhibitor: raltegravir (Isentress)NoneNoneDiarrhea, nausea, headache, increased creatine kinase levels, myopathy, rhabdomyolysis