Condition	Synonyms	Timing	Features	Important considerations	Prognosis
Atopic eruption of pregnancy	Prurigo, early-onset prurigo, pruritic folliculitis, or eczema of pregnancy; prurigo gestationis	Second trimester (75 percent of patients affected before third trimester)	Two-thirds of patients have widespread eczematous changes, mainly on flexural sites^1,2 One-third of patients have focal lesions; follicular, papular, or pustular Generalized xerosis	Most common dermatosis in pregnancy Affects patients with personal or family history of atopy⁵	Good maternal response to treatment No fetal effects or lesions New born at high risk of developing atopy
Atopic eruption of pregnancy		Tends to recur in subsequent pregnancies
Intrahepatic cholestasis of pregnancy^1,2	Cholestasis of pregnancy, obstetric cholestasis, jaundice of pregnancy, pruritus gravidarum, prurigo gravidarum, icterus gravidarum	Third trimester	Sudden onset of intense pruritus Often starts on palms or soles, then becomes generalized Only secondary skin changes from scratching are apparent	Elevated total serum bile acid levels	Fetal risks include prematurity (19 to 60 percent), intrapartum fetal distress (22 to 33 percent), and fetal demise (1to 2 percent)^6,7 Close monitoring with delivery after lungs mature reduces fetal risks Maternal risks include steatorrhea with vitamin K deficiency and bleeding complications
Intrahepatic cholestasis of pregnancy^1,2		Tends to recur in subsequent pregnancies		Elevated total serum bile acid levels
Pemphigoid gestationis	Herpes gestationis	Third trimester or postpartum	Intense pruritus precedes urticarial plaques or papules surrounding umbilicus Spreads rapidly and forms bullae	Autoimmune disorder with increased lifetime risk of Graves disease Skin biopsy is needed to confirm diagnosis	Risk of fetal growth restriction³ Antepartum fetal testing is warranted Causes lesions in 10 percent of newborns
Pemphigoid gestationis	Herpes gestationis	Tends to recur in subsequent pregnancies
Polymorphic eruption of pregnancy	Pruritic urticarial papules and plaques, polymorphic eruption, toxic erythema, toxemic rash, or late-onset prurigo of pregnancy	Late third trimester and postpartum, most often in primigravida	Mainly papulourticarial Starts within striae, coalesces into plaques, and spreads to buttocks and proximal thighs; spares umbilical region	Occurs in one in 160 pregnancies⁴ Typically resolves within four to six weeks ⁵ Associated with excessive maternal weight gain and multiple gestation⁶	Excellent maternal and fetal prognoses No cutaneous involvement in newborn
Polymorphic eruption of pregnancy		Does not tend to recur in subsequent pregnancies