Test	Description	Advantages	Disadvantages
Eucapnic voluntary hyperpnea test	Patient hyperventilates a mixture of cold, dry air	Sensitive and specific Less laboratory space and equipment needed	Need to control inspired gases and humidity Need to monitor minute ventilation Relatively expensive Not readily available
Eucapnic voluntary hyperpnea test	Spirometry performed before and after hyperventilation
Field-based exercise challenge	Usually performed in the environment that causes symptoms	Sensitive and specific for cold-weather athletes Readily available Minimal equipment Inexpensive	Not standardized Unable to control environment
Field-based exercise challenge	Spirometry performed before and after exercise		Not standardized Unable to control environment
Hypertonic saline test	Patient is given nebulized hypertonic saline	Sensitive and specific Less laboratory space and equipment needed	Not as reliable if patient is already being treated with inhaled corticosteroid
Hypertonic saline test	Spirometry performed before and after nebulization
Laboratory-based exercise challenge	Usually performed on a treadmill or stationary bike	ensitive and specific Standardized	Need to control inspired gases and humidity Need to monitor heart rate and minute ventilation Relatively expensive
Laboratory-based exercise challenge	Spirometry performed before and after exercise	ensitive and specific Standardized