| Drug | Short term (five to 10 days) | Long term (more than 21 days) | |||||
|---|---|---|---|---|---|---|---|
| Continuity | REM sleep | REM sleep latency | Continuity | REM sleep | REM sleep latency | Withdrawal REM rebound | |
| MAOI | |||||||
| Phenelzine (Nardil) | ∝ | *** | ††† | ∝ | *** | ††† | † |
| SSRI | |||||||
| Citalopram (Celexa), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft) | ↔ | ** | ††† | ↔ | ** | †† | † |
| Fluoxetine (Prozac) | ↓ | ** | † | ↓ | * | † | ∝ |
| TCA | |||||||
| Amitriptyline | ↔ | ** | †† | ↑ | * | †† | † |
| Imipramine (Tofranil) | ↔ | ** | ††† | ↔ | * | †† | ∝ |
| Other | |||||||
| Bupropion (Wellbutrin) | ∝ | ∝ | ∝ | ↔ | ↔/↓ | †/↔ | ∝ |
| Mirtazapine (Remeron) | ↑ | ↔ | ↔ | ↑ | ↔ | †/↔ | ∝ |
| Nefazodone | ↑ | ↔ | ↔ | ↑ | ↔ | ↔/↓ | ∝ |
| Trazodone | ↔/↑ | * | † | ↑ | ↔ | † | ∝ |