Medication	Initial dosage	Maximal dosage	Risk of drug interaction	Adverse effects*
Selective serotonin reuptake inhibitors
Citalopram (Celexa)	10 to 20 mg once per morning	40 mg once per day	Low	Hyponatremia, GI symptoms, sexual dysfunction, weight gain, extrapyramidal symptoms
Escitalopram (Lexapro)	10 mg once per day	20 mg once per day	Low	GI symptoms, sexual dysfunction, weight gain
Fluoxetine (Prozac)	10 to 20 mg once per day	40 mg once per day	High	Insomnia, GI symptoms, sexual dysfunction, weight gain
Paroxetine (Paxil)	10 mg once per day	40 mg once per day	Moderate	GI symptoms, sedation, weight gain, withdrawal symptoms
Sertraline (Zoloft)	25 to 50 mg once per day	200 mg once per day	Low	Sexual dysfunction, weight gain
Serotonin-norepinephrine reuptake inhibitors
Duloxetine (Cymbalta)	20 mg once or twice per day	60 mg once per day or 30 mg twice per day	Low	GI symptoms, xerostomia, urinary hesitancy
Venlafaxine (Effexor)	25 to 50 mg twice per day	75 to 225 mg total twice per day	High	GI symptoms, headaches, hyponatremia, withdrawal symptoms, hypertension, extrapyramidal symptoms
Other serotonergic agents
Bupropion (Wellbutrin)†	37.5 to 50 mg twice per day	75 to 150 mg twice per day	Moderate	GI symptoms, sexual dysfunction, seizures, psychosis
Mirtazapine (Remeron)	7.5 to 15 mg at bedtime	45 mg once per day	Low	Sedation, sexual dysfunction, weight gain
Tricyclic agents
Desipramine (Norpramin)	10 to 25 mg once at bedtime	50 to 150 mg once per day	High	Hypotension, sedation, GI symptoms, weight gain
Nortriptyline (Pamelor)	10 to 25 mg once at bedtime	75 to 150 mg once per day	High	Hypotension, sedation, weight gain