Drug	Dosage	Cost (brand)*†	Adverse effects	Advantages	Disadvantages	Pregnancy category‡	Use in children
Atovaquone/proguanil (Malarone)	250/100 mg per day one to two days before travel through seven days after return	$153 ($192) for 23 pills	Abdominal pain, nausea, vomiting, elevated alanine transaminase levels	Only continued for seven days after return instead of four weeks	Contraindicated in patients with creatinine clearance < 30 mL per minute per 1.732 (0.50 mL per second per m2)	C	May be used in children older than one month
Doxycycline	100 mg per day one to two days before travel through four weeks after return	$19 for 44 pills	Photosensitivity, vaginal candidiasis, abdominal pain, diarrhea	Offers additional protection against tick-borne illnesses; can treat comorbid acne vulgaris	Must continue daily for four weeks after return from travel	D	Contraindicated in children younger than eight years
Mefloquine	250 mg per week one week before travel through four weeks after return	$70 for 7 pills	Insomnia, paranoia, hallucinations, seizures	Weekly medicine	Causes QT prolongation and/or bradycardia in patients with abnormal cardiac conduction	May be used in the second or third trimester	May be used in children older than three months
Chloroquine (Aralen)	500 mg per week one to two weeks before travel through four weeks after return	$42 ($61) for 8 pills	Blurry vision, tinnitus, hearing loss	Weekly medicine	Plasmodium falciparum is largely resistant	May be used in all trimesters	May be used in children of all ages
Primaquine [ corrected]	30 mg per day of primaquine (52.6 mg of primaquine phosphate) for one to two days before travel through seven days after return	$45 for 23 pills	Abdominal pain, nausea, vomiting, acute hemolysis in patients with G6PD deficiency	Only continued for seven days after return instead of four weeks	Can be used only in areas with Plasmodium vivax transmission	C	May be used in children of all ages
	Note: 15 mg of primaquine = 26.3 mg of primaquine phosphate