Intervention	Background and rationale	Source of recommendation
Don't perform imaging for low back pain within the first six weeks unless red flags are present (FM, IM) note: Red flags include, but are not limited to, severe or progressive neurologic deficits or when serious underlying conditions such as osteomyelitis are suspected	Imaging of the lumbar spine before six weeks does not improve outcomes, but does increase cost Low back pain is the fifth most common reason for all physician visits	Agency for Health Care Policy and Research Cochrane Database of Systematic Reviews
Don't routinely prescribe antibiotics for acute, mild to moderate sinusitis unless symptoms (which must include purulent nasal secretions and maxillary pain or facial or dental tenderness to percussion) last for at least seven days or symptoms worsen after initial clinical improvement (FM)	Most cases of maxillary sinusitis in the ambulatory setting are caused by a viral infection that will resolve on its own Despite consistent recommendations to the contrary, antibiotics are prescribed in more than 80 percent of outpatient visits for acute sinusitis Sinusitis accounts for 16 million office visits and $5.8 billion in annual health care costs	Annals of Internal Medicine Cochrane Database of Systematic Reviews
Don't order annual electrocardiography or any other cardiac screening for asymptomatic, low-risk patients (FM, IM)	Little evidence that detection of coronary artery stenosis improves health outcomes in asymptomatic patients at low risk of coronary heart disease False-positive test results are likely to lead to harm through unnecessary invasive procedures, overtreatment, and misdiagnosis Potential harms of routine annual screening exceed the potential benefit	USPSTF
Don't perform Pap tests in patients younger than 21 years or in women after hysterectomy for benign disease (FM)	Most dysplasia in adolescents regresses spontaneously; therefore, screening Pap tests in this age group can lead to unnecessary anxiety, morbidity, and cost Pap tests have low yield in women after hysterectomy for benign disease, and there is poor evidence for improved outcomes	American College of Obstetricians and Gynecologists (for age) USPSTF (for hysterectomy)
Don't use dual energy x-ray absorptiometry to screen for osteoporosis in women younger than 65 years or in men younger than 70 years with no risk factors (FM, IM) note: Risk factors include, but are not limited to, fractures after 50 years of age, prolonged exposure to corticosteroids, diet deficient in calcium or vitamin D, cigarette smoking, alcoholism, and thin/small build	Not cost-effective in younger, low-risk patients, but cost-effective in older patients	American Association of Clinical Endocrinologists American College of Preventive Medicine National Osteoporosis Foundation USPSTF
Don't obtain blood chemistry panels (e.g., basic metabolic panel) or perform urinalyses for screening in asymptomatic, healthy adults (IM)	Only lipid screening yielded a significant number of positive results among asymptomatic patients Screen for type 2 diabetes mellitus in asymptomatic adults with hypertension	USPSTF
Use only generic statins when initiating lipid-lowering drug therapy (IM)	All statins are effective in decreasing mortality, heart attacks, and strokes when dose is titrated to effect appropriate LDL cholesterol reduction Switch to more expensive brand-name statins (atorvastatin [Lipitor] or rosuvastatin [Crestor]) only if generic statins cause clinical reactions or do not achieve LDL cholesterol goals	CURVES and MERCURY trials and meta-analyses
Don't prescribe antibiotics for pharyngitis unless the child tests positive for streptococcal infection (Ped)	Most cases of pharyngitis are viral and will not respond to antibiotics, yet antibiotics are prescribed more than half of the time Antibiotic use has potential risks to the child, increases bacterial antibiotic resistance, and adds to health care expenses The absence of fever, cervical lymphadenopathy, and tonsillar exudates, and the presence of cough suggest a viral etiology; screening for streptococcal infection may be unnecessary if these criteria are present Confirmation of streptococcal infection is necessary before antibiotic use can be justified	Agency for Healthcare Research and Quality Cochrane Database of Systematic Reviews Essential Evidence Plus
Don't obtain diagnostic images for minor head injuries in children without loss of consciousness or other risk factors (Ped)	Imaging in low-risk patients rarely detects traumatic abnormalities, and of the abnormalities detected, few, if any, require surgery Higher risk factors include dizziness, external signs of injury, changes in neurologic function, a dangerous mechanism of injury (e.g., bicycle-related injury, a fall from 3 ft or more or five stairs), age younger than two years, Glasgow Coma Scale score of less than 15, and evidence of basilar skull fracture (e.g., “raccoon eyes,” hemotympanum) Early exposure to radiation poses a significant risk of radiation-attributed cancers—as high as one case in 1,400 infants exposed to cranial computed tomography	AAFP/AAP guidelines
Don't refer children who have otitis media with effusion early in the course of the problem (Ped)	Many cases of otitis media with effusion resolve spontaneously within three months with no adverse consequences Reasons for early referral include craniofacial or neurologic abnormalities, language delay or learning problems, and suspected structural abnormalities of the eardrum or middle ear	AAFP/AAP guidelines National Institute for Health and Clinical Excellence
Advise that children not use cough and cold medications (Ped)	There is little evidence that over-the-counter cough and cold medications reduce cough or rhinorrhea, or shorten the duration of illness in children; rather, they can cause adverse consequences, including death Yet, more than 10 percent of children use a cough and cold medication every week	AAP Cochrane Database of Systematic Reviews U.S. Food and Drug Administration
Use inhaled corticosteroids to appropriately control asthma in children (Ped)	Use of a controlling medication for persistent asthma reduces asthma exacerbations, emergency department visits, and hospital admissions Threshold: More than four wheezing episodes or two episodes requiring oral corticosteroids within six months Inhaled corticosteroids are relatively safe and well tolerated	National Asthma Education and Prevention Program