Agent	FDA pregnancy category	Adverse effects	Available formulations	Estimated cost generic (brand)*
Adapalene (Differin)	C	Local erythema, peeling, dryness, pruritus, stinging	Cream, lotion (0.1%)	$125 ($363)
			Gel (0.1%, 0.3%)
			Adapalene/benzoyl peroxide (Epiduo) gel (0.1%/2.5%)	NA ($269)
Tazarotene (Tazorac)	X	Local erythema, peeling, dryness, pruritus, stinging	Cream, gel (0.05%, 0.1%)	NA ($240)
Tretinoin (Retin-A)	C	Local erythema, peeling, dryness, pruritus, stinging	Cream (0.025%, 0.05%, 0.1%)	$27 ($130)
			Gel (0.01%, 0.025%, 0.05%)	$24 ($19 to $105)
			Microsphere gel (0.04%, 0.1%)	NA ($170)