| Acetic acid 2% (Vosol) | $39 for 15 mL* ($36 for 15 mL)* | Four to six times daily | No | May cause pain and irritation; may be less effective than other treatments if use is required beyond one week; often used as prophylactic agent |
| Ciprofloxacin 0.3%/dexamethasone 0.1% (Ciprodex) | Not available ($160 for 7.5 mL)* | Twice daily | Yes | Low risk of sensitization |
| Hydrocortisone 2%/acetic acid 1% (Vosol HC) | $220 for 10 mL† ($215 for 10 mL)* | Four to six times daily | No | May cause pain and irritation |
| Neomycin/polymyxin B/hydrocortisone, solution or suspension | $28 for 10-mL solution; $30 for 10-mL suspension† ($85 for 10-mL solution; $78 for 10-mL suspension)† | Three to four times daily | No | Ototoxic; higher risk of contact hypersensitivity; avoid in chronic/eczematous otitis externa4 |
| Ofloxacin 0.3% | $60 for 5 mL; $93 for 10 mL† ($80 for 5 mL; $143 for10 mL)† | Once to twice daily | Yes | Low risk of sensitization |
