Treatment	Evidence
NSAIDs	A 2009 Cochrane review including only one small RCT of naproxen versus placebo showed no conclusive evidence that NSAIDs improve pain; however, because NSAIDs are effective for primary dysmenorrhea, consensus opinion suggests they are reasonable as a first-line treatment for suspected endometriosis30
Combination oral contraceptives	A 2007 Cochrane review including only one study comparing combination oral contraceptives with gonadotropin-releasing hormone analogues showed that both were comparable for pain relief 31; a Japanese RCT showed that low-dose combined oral contraceptives improved pain compared with placebo32
Medroxyprogesterone	Small RCTs show that oral medroxyprogesterone (Provera) and depot medroxyprogesterone (Depo-Provera, Depo-subQ Provera) are beneficial for pain33,34
Levonorgestrel-releasing intrauterine system (Mirena)	Small nonrandomized studies show possible benefit for pain33,35
Gonadotropin-releasing hormone analogues	A 2010 Cochrane review showed effectiveness36; however, adverse effects (i.e., menopausal symptoms) limit its use
Danazol	A 2007 Cochrane review showed effectiveness37; however, androgenic adverse effects limit its use