CIN 2/3 with unsatisfactory colposcopy (recommended)

Recurrent CIN 2/3 (recommended)

CIN 2/3 with satisfactory colposcopy (option)

CIN 2/3 with satisfactory colposcopy (option)

Endocervical sampling shows CIN 2/3 (recommended)

CIN 1 preceded by HSIL or atypical squamous cells, cannot exclude HSIL (option)

HSIL cytology “see and treat” (option)

Persistent CIN 1 for at least two years (option)

Potential cautery artifact at the margins precluding margin status

Potential post-LEEP stenosis if crater rim is excessively cauterized

Potential bleeding at the time of LEEP or during postoperative period

Associated with an increased risk of preterm labor and low birth weight

Same as for LEEP, but preferable when margin status is critical for determining residual disease (e.g., adenocarcinoma in situ, squamous microinvasive disease)

Higher rate of hemorrhage than LEEP

Removes more tissue than LEEP

Associated with an increased risk of preterm labor and low birth weight

Consistently associated with extreme preterm labor and delivery (< 28 weeks) and low birth weight (< 2,000 g [4 lb, 6 oz]), whereas LEEP is not

Satisfactory colposcopy

Benign endocervical curettage

Invasion not present

Entire lesion visible

Lesion size ≤ two quadrants

No specimen available for histologic analysis

Risk of preterm labor not increased

Same as for cryotherapy, but lesion extends into the fornix

Risk of preterm labor not increased with laser ablation

Risk of preterm labor increased if depth of laser conization > 10 mm