Infection*Source patient's disease statusStatus of exposed personRegimen
Hepatitis A virusSerologically confirmed case within incubation period until one week after onset of jaundiceUnvaccinatedA single dose of hepatitis A vaccine within two weeks of exposure
Unvaccinated, immunocompromised, chronic liver disease, younger than 12 months, or severe allergy to vaccineA single dose of immune globulin (0.02 mL per kg IM) within two weeks of exposure
Varicella zoster virusFrom one to two days before onset of rash until after all lesions have crustedNonimmune (i.e., no history of varicella and negative serology) who has not received two doses of vaccineHealthy persons: varicella vaccine within five days of exposure
Pregnant women, neonates, or immunocompromised persons: varicella zoster immune globulin (125 units per 10 kg IM) as soon as possible (up to 10 days postexposure), or immune globulin (400 mg per kg IV) if varicella zoster immune globulin is unavailable
InfluenzaFrom one day before onset of symptoms until one day after defervescence (may be longer for immunocompromised patients)High-risk groupUnvaccinated persons: influenza vaccine
RabiesBites or scratches from a suspected rabid animal; contamination of a mucous membrane or open wound with saliva or central nervous system tissue from a suspected rabid animalPreviously unvaccinatedRabies vaccine should be given as early as possible on days 0, 3, 7, and 14 postexposure, in addition to human rabies immune globulin (20 units per kg in a single dose) on day 0. Rabies immune globulin should be infiltrated around the wounds first if anatomically feasible, with the rest administered IM into the gluteal region. If the person is immunocompromised, a fifth dose of rabies vaccine should be given on day 28.§
Previously vaccinated||Rabies vaccine only on days 0 and 3 with documentation of protective neutralizing antibodies (> 0.5 IU per mL); otherwise give vaccine on days 0, 3, 7, 14, and 28 postexposure