Amoxicillin (80 to 90 mg/kg per day in 2 divided doses)

Or

Amoxicillin-clavulanate* (90 mg/kg per day of amoxicillin, with 6.4 mg/kg per day of clavulanate [amoxicillin to clavulanate ratio, 14:1] in 2 divided doses)

Cefdinir (14 mg/kg per day in 1 or 2 doses)

Cefuroxime (30 mg/kg per day in 2 divided doses)

Cefpodoxime (10 mg/kg per day in 2 divided doses)

Ceftriaxone (50 mg/kg IM or IV per day for 1 or 3 days, not to exceed 1 g per day)

Amoxicillin-clavulanate* (90 mg/kg per day of amoxicillin, with 6.4 mg/kg per day of clavulanate in 2 divided doses)

Or

Ceftriaxone (50 mg/kg IM or IV per day for 1 or 3 days, not to exceed 1 g per day)

Ceftriaxone, 3 d clindamycin (30–40 mg/kg per day in 3 divided doses), with or without third-generation cephalosporin

Failure of second antibiotic

Clindamycin (30–40 mg/kg per day in 3 divided doses) plus third-generation cephalosporin

Tympanocentesis†

Consult specialist†