Contraindications

Encephalopathy not attributable to another cause occurring within seven days after vaccination with DTP or DTaP

History of anaphylactic reaction to the vaccine or its components

Precautions

Collapse or shock-like state within 48 hours of receiving DTP or DTaP vaccine

Guillain-Barré syndrome < six weeks after receiving a tetanus toxoid–containing vaccine

History of arthus (type III hypersensitivity) reactions after receiving a tetanus toxoid–containing vaccine

History of fever ≥ 105°F (≥ 40.5°C) within 48 hours of receiving DTP or DTaP vaccine

Inconsolable crying in infants/children > three hours after receiving DTP or DTaP vaccine

Moderate to severe acute illness, with or without fever

Progressing neurologic disorder (i.e., infantile spasm, seizure, encephalopathy) until condition has stabilized

Seizure ≤ three days after receiving DTP or DTaP vaccine

Adverse drug reactions

Mild reactions include fever, drowsiness, fretfulness, anorexia, headache, fatigue, and pain at injection site

Moderate to severe systemic events include extensive limb swelling, arthus reactions, temperature ≥ 105°F (≥ 40.5°C), febrile seizures, persistent crying in infants/children > three hours, and hypotonic hyporesponsive episodes