| Addison disease, or primary adrenal insufficiency, is diagnosed after confirming an elevated ACTH level and an inability to stimulate cortisol levels with a cosyntropin stimulation test. | C | 12, 22 |
| Addison disease should be treated with a glucocorticoid (i.e., daily prednisone, twice daily hydrocortisone, or daily dexamethasone in situations when oral therapy is not tolerated). Treatment should be titrated to the lowest dose that relieves symptoms. [corrected] | C | 16–20 |
| Addison disease should be treated with a mineralocorticoid (i.e., daily fludrocortisone). Treatment should be titrated to keep the plasma renin activity in the upper normal range. | C | 21, 22 |
| Dehydroepiandrosterone (DHEA) therapy may improve depression symptoms and health-related quality of life in women. | B | 23 |
| Physicians should remain vigilant for the development of concomitant autoimmune disorders in patients with Addison disease. | C | 8, 28–34 |
